There's Figma as an Illustrator or Sketch competitor ... and that's one of the few creative programs built as a collaborative web app. While CRMs, project management, email tools, database builders, and more went online over the past couple decades, there are still a wide variety of software that's stuck on the desktop.
What desktop software do you still use, things that still don't have a web app alternative and aren't built around collaboration?
The Adobe Creative Suite, Techsmith Camtasia (product videos), and Microsoft Office (50% desktop/50% online). Web Outlook is actually really good and I've been trying to use it 100% of the time.
Mimestream - still in public beta, but already the best desktop email client I've used in a while. Essentially an Apple Mail clone, but tightly integrated into Gmail / Google Apps. Fast search, awareness of filters / tags / other organization structures that just don't translate into the Apple version of the same idea. Fast and actually native.
Writing software has always been a big one for me. Even though there are web apps for writing—even Draftin for focused writing—I've never found a web app that fit my writing workflow well. As such, I typically write in iA Writer or Ulysses on Mac or iPad, then copy that text into Google Docs for editing or our CMS to publish.
And then as @MikeRaia mentioned, Adobe Creative Suite keeps me on the desktop. Lightroom has a web app but it's far too basic; Photoshop (or other desktop alternatives like Pixelmator) still make it easier to even do simple tasks like crop and resize images than web apps do. The good thing there is, they're tasks that aren't collaborative, so they're fine confined to the desktop. InDesign is one that I'd love to see remade as a web app, in Figma's image, as publishing could absolutely benefit from being more collaborative.
Markdown is the most popular way to format plain text. Add common characters like asterisks and dashes to text, much like how you might format a quick store list in your notes app or add emphasis ...
Or do you use the Linux subsytem in Windows, emulation tools like DosBOX and WINE, or mobile device emulator/simulators? What's your favorite ways you've used virtual machines and emulation?